تأثير تنظيم البروبيوتيك والبريبايوتيك على تنوع الميكروبيوم المعوي وتحسين مؤشرات مرض الكبد الدهني غير الكحولي (NAFLD) لدى البالغين

1. Introduction 1.1 Background and Significance 1.2 Objectives of the Study 1.3 Research Questions 1.4 Methodological Approach 2. The Gut Microbiome 2.1 Composition and Function 2.2 Factors Affecting Diversity 2.3 Role in Health and Disease 3. Probiotics and Their Regulation 3.1 Definition and Types 3.2 Mechanisms of Action 3.3 Regulatory Considerations 3.4 Clinical Applications 4. Prebiotics and Their Regulation 4.1 Definition and Types 4.2 Mechanisms of Action 4.3 Regulatory Considerations 4.4 Clinical Applications 5. Non-Alcoholic Fatty Liver Disease (NAFLD) 5.1 Pathophysiology and Stages 5.2 Epidemiology and Risk Factors 5.3 Biomarkers and Diagnosis 6. Impact on Gut Microbiome Diversity 6.1 Influence of Probiotics 6.2 Influence of Prebiotics 6.3 Combined Effects 6.4 Case Studies 7. NAFLD Indicators Improvement 7.1 Clinical Trials and Evidence 7.2 Biochemical Markers of Improvement 7.3 Patient Outcomes and Quality of Life 8. Conclusion and Future Directions 8.1 Summary of Findings 8.2 Clinical Implications 8.3 Directions for Future Research