Investigating the Role of Microglial Cells in Neurodegenerative Diseases: A Proteomics Approach

1. Introduction 1.1 Background and Motivation 1.2 Objectives of the Study 1.3 Structure of the Thesis 2. Microglial Cells in the Central Nervous System 2.1 Definition and Function 2.2 Microglial Activation Mechanisms 2.3 Roles in Neurodegeneration 3. Overview of Neurodegenerative Diseases 3.1 Common Types and Characteristics 3.2 Pathophysiological Mechanisms 3.3 Current Challenges and Limitations 4. Proteomics: A Tool for Cellular Analysis 4.1 Introduction to Proteomics 4.2 Techniques and Technologies 4.3 Advantages and Applications 5. Proteomics in Microglial Research 5.1 Profiling Microglial Proteomes 5.2 Identifying Disease-Linked Proteins 5.3 Impacts on Neurodegenerative Study 6. Case Studies of Microglial Involvement 6.1 Alzheimer's Disease 6.2 Parkinson's Disease 6.3 Amyotrophic Lateral Sclerosis 7. Data Analysis and Interpretation 7.1 Statistical Approaches 7.2 Integration with Other Omics 7.3 Limitations and Considerations 8. Conclusion and Future Perspectives 8.1 Summary of Key Findings 8.2 Implications for Treatment Strategies 8.3 Directions for Further Research