1. Introduction 2. Overview of Microglia 2.1 Definition and Origin 2.2 Functions in the Healthy Brain 2.3 Microglial Activation Mechanisms 3. Neuroinflammation and Its Impact 3.1 Definition of Neuroinflammation 3.2 Causes of Neuroinflammation 3.3 Consequences on Neural Function 4. Role of Microglia in Neuroinflammation 4.1 Microglial Response to Injuries 4.2 Pathways of Microglial Activation 4.3 Microglia and Cytokine Release 5. Microglia in Neurodegenerative Diseases 5.1 Alzheimer's Disease and Microglia 5.2 Parkinson's Disease and Microglial Role 5.3 Amyotrophic Lateral Sclerosis (ALS) 5.4 Huntington's Disease Overview 6. Mechanisms Linking Microglia and Neurodegeneration 6.1 Protein Aggregation and Microglial Interaction 6.2 Neurotoxicity Induced by Microglia 6.3 Phagocytic Dysfunction of Microglia 7. Therapeutic Approaches Targeting Microglia 7.1 Anti-inflammatory Drug Strategies 7.2 Modulation of Microglial Activity 7.3 Potential for Gene Therapy 8. Future Directions and Challenges 8.1 Emerging Research Technologies 8.2 Challenges in Therapeutic Development 8.3 Implications for Clinical Practice
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