“Design, Formulation and Evaluation of Thiolated Chitosan-Based Gastroretentive Febuxostat Tablets”

1. Introduction 1.1 Background and Significance 1.2 Objectives of the Study 1.3 Structure of the Thesis 2. Literature Review 2.1 Chitosan and its Derivatives 2.2 Gastroretentive Drug Delivery Systems 2.3 Febuxostat Pharmacology 2.4 Thiolated Polymers in Drug Delivery 3. Materials and Methods 3.1 Materials Used 3.2 Thiolated Chitosan Synthesis 3.3 Formulation of Tablets 3.4 Evaluation Techniques 4. Design of Gastroretentive Tablets 4.1 Formulation Strategies 4.2 Drug Release Mechanisms 4.3 Optimization of Formulation 5. Formulation Techniques 5.1 Direct Compression Method 5.2 Wet Granulation Method 5.3 Comparison of Techniques 6. Evaluation of Tablets 6.1 Physicochemical Characterization 6.2 Swelling and Mucoadhesion 6.3 In Vitro Drug Release 7. Results and Discussion 7.1 Effectiveness of Thiolated Chitosan 7.2 Comparative Analysis of Formulations 7.3 Implications for Clinical Applications 8. Conclusion and Future Work 8.1 Summary of Findings 8.2 Limitations of the Study 8.3 Suggestions for Further Research